Fermented in Japan
Our nattokinase is produced by a Japanese enzyme house using Bacillus subtilis natto — the same strain behind traditional natto.
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Nattokinase®
Heart + Circulation Support
Support healthy circulation from the inside out. Novelle Nattokinase delivers 10,000 FU of nattokinase per serving alongside CoQ10, bromelain, turmeric, aged garlic extract and pine bark extract — two vegetarian capsules a day, 30 servings per bottle.
- 10,000 FU nattokinase in every daily serving
- 100% authentic nattokinase — fermented and tested in Japan
- Five complementary cardiovascular ingredients
- 60 vegetarian capsules · 30 daily servings per bottle
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Clinicians' Choice
471 clinicians recommend this formula to their patients without compensation.
Dr. Margaret Chen, MD, FACC |Medical professionalI look for formulas that are transparent about potency. 10,000 FU stated on the label, plus CoQ10 and circulation-supporting botanicals, is a combination I feel comfortable discussing with patients.
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90-day guarantee
Vegetarian capsules
10,000 FU per serving
100% authentic · Made in Japan
90-day guarantee
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Verified & tested
Trust built on Japanese proof.
Every batch is fermented, activity-tested and documented in Japan — backed by more than a thousand published studies.
Made in Japan
Fermented & tested in Japan
Produced by a Japanese enzyme house and activity-tested before release. Every lot traces back to the original fermentation run.
Published research
1,000+
Published papers referencing nattokinase and fibrinolytic activity in the indexed literature.
Ren et al., 2017Kim et al., 2008PubMed indexed
Referenced & recognised in
- Journal of Agricultural and Food Chemistry
- Nutrition Research
- PubMed indexed
- Hypertension Research
- Biomarker Insights
- Japan Nattokinase Association
Publications that have covered nattokinase research. Mentions refer to the ingredient, not to this product.
CIRCULATE
10,000
FU per serving
Why circulation
Your heart is the one muscle that never gets a day off.
Every beat pushes blood through roughly sixty thousand miles of vessels — carrying oxygen, nutrients and warmth to every corner of you.
That is what Novelle Nattokinase is. Two capsules. One purpose. Every day.
What it supports
One serving, built around circulation
Novelle Nattokinase is formulated to support heart health, healthy circulation and normal blood flow as part of a daily routine.
Supports heart health
The one muscle that never gets a night off deserves more than an afterthought. This serving is built around cardiovascular wellness rather than a single isolated nutrient.
Supports healthy circulation
Circulation is the delivery system for everything else — oxygen, nutrients, warmth. Support it daily and it quietly shapes how the rest of your day feels.
Helps maintain normal blood flow
Nattokinase sits at the centre of the formula for one reason: three decades of study on its relationship to fibrin and the free movement of blood.
Supports vessels that stay flexible
CoQ10, aged garlic extract and pine bark polyphenols round out the serving — ingredients long used for vascular tone and antioxidant support.
A routine you will actually keep
Two vegetarian capsules, once a day, with food or water. No powders, no mixing, no second alarm, nothing to rebuild your morning around.
10,000 FU — five times the usual
Potency is printed on the label in fibrinolytic units and verified per batch — no vagueness, no guessing what you swallowed.
What changes with age
Circulation is never lost overnight. It is lost in five quiet stages.
Your body produces its own enzymes to clear surplus fibrin and keep vessels supple. That activity declines with every decade — which is why circulation is something to support before you feel it, not after.
01
The quiet wear starts early
Processed food, chronic stress and years of sitting put a steady load on the delicate lining of your vessels. It happens in your forties and fifties, it is completely painless, and nothing on a routine check-up flags it.
Auto-advancing stage 1 of 5
From food to formula
The enzyme that came from breakfast.
01
A 1,000-year-old breakfast
In Japan, natto has been eaten for centuries — soybeans fermented with Bacillus subtilis until they turn sticky, pungent and unmistakable.
02
The enzyme researchers noticed
What interested scientists was not the flavor but the fermentation. That process produces nattokinase, an enzyme studied for its relationship to fibrin and blood flow.
03
Concentrated, not recreated
You do not have to learn to love natto. We standardize the enzyme to 10,000 FU and put it in a clean, vegetarian capsule.
Origin
100% authentic nattokinase — made in Japan
Nattokinase was discovered in Japan, and that is still the only place we will source it from. Every serving in this bottle is fermented, extracted and activity-tested in Japan.
Verify this batch
Every lot ships with a Japanese certificate of analysis
Enzyme activity, heavy metals and microbiology — tested in Japan, documented per lot. Scan the code or open the certificate to read the full results yourself.
View the certificate
Scan to verifyJapanese-standard testing
Every lot is assayed in Japan for enzyme activity, purity and heavy metals before it is ever released.
Certificate of analysis
A Japanese certificate of analysis follows each batch, confirming a minimum of 10,000 FU of activity per serving.
Traceable from Japan to you
Lot numbers trace back to the Japanese production run — no anonymous bulk enzyme, no mystery sourcing.
Authenticity promise
If it does not come from Japan, it does not go in the bottle. 100% authentic Japanese nattokinase, 10,000 FU per serving — verified in Japan, encapsulated for you.
The ancient Japanese answer
What changes when the enzyme goes back in
Nattokinase is concentrated from the very same fermentation Japanese households have eaten at breakfast for a thousand years — then paired with seven ingredients chosen around one single theme: circulation.
01
Blood that moves freely again
Nattokinase is the enzyme at the centre of the formula — the same one produced when soybeans ferment into natto, and the one researchers have spent three decades studying for its relationship to fibrin and the free movement of blood.
Nattokinase is the enzyme at the centre of the formula — the same one produced when soybeans ferment into natto, and the one researchers have spent three decades studying for its relationship to fibrin and the free movement of blood.
What the research reports
Three decades of study on one Japanese enzyme
Nattokinase is one of the most researched enzymes in the wellness category. These are published findings from human trials of nattokinase as an ingredient — not claims about this product.
36.6%
average reduction in carotid plaque size reported in a 26-week nattokinase trial
Ren et al., 2017
5.6 mmHg
average drop in systolic pressure over 8 weeks in an 86-person trial
Kim et al., 2008
1,000+
published papers referencing nattokinase and fibrinolytic activity
PubMed, indexed literature
10,000 FU
of enzyme activity in every single daily serving of Novelle
On our label, per batch CoA
Made in Japan2 capsules a day30 servings per bottle8 ingredients, all named
Figures refer to published research on nattokinase as an ingredient. Individual results vary. This product is not intended to diagnose, treat, cure or prevent any disease.
Read it yourself
The papers behind the claims.
Every figure we quote traces back to published human research. Here are the primary sources — links go straight to PubMed.
Studies refer to nattokinase as an ingredient, not to this finished product. These statements have not been evaluated by the FDA.
A thousand-year habit
Why Japanese circulation stays remarkable into the nineties
Natto is a fermented soybean breakfast food — pungent, sticky, and eaten daily across Japan for over a thousand years. Nattokinase is the enzyme that fermentation produces, and it is the single reason a humble breakfast dish ended up under a microscope in the first place. Japan kept the habit. The West only recently discovered the enzyme.
The Western realityThe Japanese advantage
Slowing circulation is accepted as a normal part of getting older
Circulation is treated as something you maintain every single morning
Nothing is done until a check-up finally says something
The habit starts decades before anyone is worried about it
Cardiovascular support scattered across three or four bottles
One serving: the enzyme, the coenzyme and four supporting botanicals
Potency buried inside a vague proprietary blend
10,000 FU of enzyme activity printed on the front of the label
Routines abandoned after a few busy weeks
Two capsules a day — simple enough to survive a busy decade
Potency, stated plainly
Why we print 10,000 FU on the label.
Milligrams tell you how much material is in a capsule. FU — fibrinolytic units — tell you how active the enzyme actually is. For an enzyme, only the second number means anything.
MetricWhat it tells you
Milligrams on the labelWeight only
Novelle Nattokinase — 10,000 FUActual enzyme activity
The point: two capsules can weigh the same and deliver very different activity. We state the number that matters.
Potency, compared
Why a 5X serving matters when a standard capsule doesn't
Most nattokinase on the shelf sits at 2,000 FU — enough to appear on an ingredient list, rarely enough to be the reason you take it. FU measures how active the enzyme actually is, not how much powder was pressed into the capsule.
Typical low-dose capsule2,000 FU
Common mid-range formula5,000 FU
Novelle Nattokinase10,000 FU
Figures shown for typical products are illustrative of the range commonly found on labels. Always check the stated FU on any nattokinase product you compare.
The complete formula
Six ingredients, one theme.
Nothing here is filler. Each addition was chosen because it belongs in a formula about circulation and cardiovascular wellness.
A naturally derived enzyme traditionally associated with natto, a Japanese fermented soybean food. Nattokinase has been studied for its relationship to fibrin and circulation, which is why it sits at the center of this formula.
CirculationNormal blood flowVascular wellness
What's in it, what isn't
Read the label before you buy.
Every suitability question people email us about, answered in one place.
Made in Japan
Fermented and assayed by a Japanese enzyme producer
Non-GMO
Non-GMO soybeans, verified per batch
Gluten free
No wheat, barley or rye in the formula
Dairy free
No milk derivatives or lactose
Vegetarian capsules
Plant-based capsule shell — no gelatin
No artificial fillers
No artificial colours, flavours or sweeteners
Third-party tested
Heavy metals, microbials and enzyme activity
Made without stimulants
Caffeine free — take it any time of day
Contains
- Soy (nattokinase is fermented from soybeans)
- Pineapple-derived bromelain
Manufactured in a facility that also handles soy. If you have a soy or pineapple allergy, do not take this product.
Free from
- Gluten
- Dairy
- Egg
- Shellfish
- Tree nuts
- Peanuts
No artificial colours, flavours, sweeteners or stimulants. Two vegetarian capsules, nothing added for show.
What to expect
Circulation moves on its own timeline.
An honest map of the first 90 days — so you know what you are looking for, and when.
Days 1–14
The habit lands
Two capsules with your morning routine. Nothing dramatic should happen yet — the enzyme is simply entering your daily rhythm, and consistency is the only thing that matters in this window.
Weeks 3–6
The early signals
This is where most people first mention something: warmer hands and feet, steadier energy through the afternoon, less heaviness in the legs after a long day. It is subtle by design.
Weeks 8–12
The full protocol
Clinical work on nattokinase generally runs 8 weeks or longer before measuring outcomes. This is why we recommend three bottles: 90 days is the shortest honest trial of a circulation routine.
Individual results vary. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Lab verified
Tested, then stated. In that order.
Nattokinase is only worth taking if the enzyme activity in the bottle matches the number on the label. Every batch is produced in Japan under GMP conditions and checked for identity, potency and purity before it ships.
- Enzyme activity verified against the stated 10,000 FU per serving
- Screened for heavy metals, microbes and contaminants
- Every ingredient named on the label, with the nattokinase dose stated in FU
How to take it
Simple enough to actually stick to
No powders to mix, no cycling schedule, no second alarm. The best supplement routine is the one that survives a busy week.
01
Two capsules, once a day
One serving is two vegetarian capsules, taken together with water — with or without food, whichever you'll remember.
02
Pick a moment and keep it
Morning coffee, lunch, evening wind-down. Consistency does more than timing ever will, so anchor it to something you already do.
03
Let the bottle run its course
60 capsules is 30 daily servings — a full month of an unbroken habit from a single bottle.
Quality
Held to the standard we'd want.
We ferment and activity-test in Japan, use vegetarian capsules, and name every ingredient on the label. No hidden doses, no mystery sourcing.
Lot verificationPassed
Made in Japan
100% authentic nattokinase, fermented and activity-tested in Japan.
Japanese COA
A certificate of analysis issued in Japan for every batch.
Vegetarian capsules
60 capsules per bottle — 30 daily servings.
Stated potency
10,000 FU of nattokinase per serving.
Full disclosure
Every ingredient named on the label.
This product is not intended to diagnose, treat, cure or prevent any disease.
In their words
People who decided not to wait.
Why customers added Novelle Nattokinase to their daily routine.
4.8
7,139 verified reviews
- 5 ★77%
- 4 ★17%
- 3 ★4%
- 2 ★1%
- 1 ★1%
Verified buyer reviews collected post-purchase. Reviews are matched to a real order before they are published.
It fits the way I already live
“I walk four miles most mornings and I want to still be doing that at eighty. Two capsules with breakfast is the least complicated thing in my whole routine.”
I stopped putting it off
“My father had heart trouble in his sixties. I did not want to wait until something happened to start paying attention to my circulation. This felt like a sensible place to begin.”
I like knowing what I'm taking
“The label tells you exactly 10,000 FU of nattokinase and names every ingredient in the bottle. After years of vague labels, that alone sold me.”
One bottle, one habit
“I was taking CoQ10 and a turmeric capsule separately and forgetting both. Having them together with the nattokinase means I actually stay consistent.”
We take it together
“We keep the bottle next to the coffee maker and take our servings at the same time. It has quietly become part of the morning.”
Peace of mind, honestly
“I travel more now than I did at forty. Knowing I am doing something steady for my cardiovascular wellness makes me feel better about all of it.”
More written reviews
12 of 7,139Easy to keep up with
“Two capsules with breakfast, no aftertaste, no upset stomach. I've finished three bottles and I've never once forgotten a day, which is more than I can say for the last thing I tried.”
Bought it for the FU number
“Most brands only print milligrams, which tells you nothing about activity. Seeing 10,000 FU on the front and the origin on the back is why I picked this one.”
My hands aren't as cold
“I can't say much scientifically, but around week six my hands and feet stopped feeling icy in the evenings. My husband noticed before I did.”
Cleared it with my doctor first
“I take a statin, so I brought the label to my appointment. My doctor read the ingredients and had no objection. Four months in and my routine hasn't changed otherwise.”
Good, though not overnight
“I expected something in the first couple of weeks and honestly felt nothing. By the second bottle my afternoon energy was steadier. Worth it, just be patient.”
Tastes like nothing, which is the point
“I grew up eating natto so I know the smell. The capsules have none of it. Knowing the fermentation is done in Japan matters to me more than the price.”
Trusted by practitioners
Clinicians' Choice.
471 doctors, pharmacists and wellness practitioners recommend Novelle Nattokinase to their patients — without compensation.
471
clinicians recommend
12
cardiology & endocrine specialists
0
paid endorsements
Dr. Margaret Chen, MD, FACC
Cardiologist · 22 years in practice
“I look for formulas that are transparent about potency. 10,000 FU stated on the label, plus CoQ10 and circulation-supporting botanicals, is a combination I feel comfortable discussing with patients.”
Dr. James Okonkwo, MD
Endocrinologist · Academic hospital system
“Patients ask about nattokinase constantly. What matters is potency, sourcing and clarity. This formula checks those boxes without overpromising — and the 90-day guarantee removes the risk of a first try.”
Dr. Sarah Whitmore, NP, IFMCP
Functional medicine practitioner
“Circulation is downstream of so many things. I appreciate that this product keeps the formula tight: enzyme support, antioxidant botanicals and no unnecessary fillers. That simplicity makes adherence easier.”
Dr. David Park, PharmD
Clinical pharmacist · Formulation advisor
“From a formulation standpoint, the ingredient choices make sense together. Nattokinase at a standardized FU level, paired with aged garlic, pine bark and CoQ10, is a thoughtful daily stack for cardiovascular wellness.”
These are independent professional opinions. Individual results may vary. This product is not intended to diagnose, treat, cure or prevent any disease.
Risk-free
Your order is protected by our 90-day money-back guarantee
Every batch is tested
Identity, potency and purity are checked before a bottle leaves the facility, so the 10,000 FU on the label is the 10,000 FU in the capsule.
90 days to decide
Cardiovascular wellness is a long game, not a week-long experiment. Take it daily for three full months and judge it properly.
Refunds without the runaround
Email info@try-novelle.com within 90 days and we will refund your order — opened bottles included. No forms, no return shipping games.
Compare
Why not the $15 bottle?
Nattokinase is sold everywhere. The differences are all in the details most labels skip.
Feature
Novelle
Typical nattokinase
Nattokinase potency
10,000 FU per serving
2,000 FU per serving
Origin
Fermented & assayed in Japan
Unspecified or blended origin
Certificate of analysis
Published, scannable per batch
On request, if at all
Supporting ingredients
CoQ10, bromelain, turmeric, aged garlic, pine bark, grape seed, dandelion
Nattokinase alone
Potency stated in FU
Printed on the front label
Often listed in mg only
Capsule shell
Vegetarian
Usually gelatin
Guarantee
90 days, opened bottles, no return shipping
30 days, unopened only
Comparison reflects commonly sold 2,000 FU nattokinase products at time of writing.
Safety first
Who should not take this.
We would rather lose the sale than have you take something that isn't right for you.
If you take blood thinners, talk to your doctor first
Nattokinase is studied for its relationship to fibrin and blood flow. If you take warfarin, clopidogrel, aspirin therapy or any anticoagulant or antiplatelet medication, do not start this product before reviewing it with your doctor or pharmacist.
Stop 2 weeks before any scheduled surgery
Standard practice for circulation-supporting supplements. Pause use at least 14 days before surgery or a dental procedure and resume only when your clinician clears you.
Not for everyone
Not intended for anyone under 18, or for those who are pregnant or nursing. Avoid if you have a bleeding disorder, an active ulcer, or a soy allergy.
What people typically notice
Nattokinase is generally well tolerated. Occasionally people report mild digestive upset in the first few days — taking the serving with food usually settles it. Stop use and contact your clinician if anything feels off.
This page is educational and is not medical advice. Always review new supplements with your healthcare professional, especially if you take prescription medication.
Try it for 90 days. On us.
Take it daily for three months. If it is not right for you, email info@try-novelle.com within 90 days and we will refund your order — opened bottles included. No forms, no return shipping games.
90-day money-back guaranteeFree US shippingNo subscription required
Questions
Everything people ask before their first bottle.
If you do not see your question, email us at info@try-novelle.com.
Yes — 100% authentic, made in Japan. Our nattokinase is fermented from soybeans by a Japanese enzyme producer using the traditional Bacillus subtilis natto strain, then assayed in Japan for activity, purity and heavy metals. Every batch ships with a Japanese certificate of analysis confirming a minimum of 10,000 FU per serving.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Consult your healthcare professional before use, particularly if you are pregnant, nursing, taking medication or have a medical condition.